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‣ Prevalência de doença periodontal e estratificação do risco cardiovascular de Framingham e PROCAM de pacientes do Instituto Dante Pazzanese de Cardiologia; Prevalence Study of periodontal disease and cardiovascular disease stratification risk in Dante Pazzanese Cardiology Institute

Silva, Leopoldo Penteado Nucci da
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 11/04/2008 Português
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Este estudo teve por objetivo avaliar a prevalência de doença periodontal e risco de doença cardiovascular estratificado pelos métodos de Framingham e PROCAM em uma amostra de sujeitos do Instituto Dante Pazzanese de Cardiologia. Trata-se de um estudo de prevalência com 56 sujeitos do gênero masculino de 45 a 70 anos dos Ambulatórios de Coronariopatia e Cardiologia do Esporte que aceitaram participar voluntariamente e tiveram os dados coletados da anamnese, do exame clínico global e periodontal e de análises laboratoriais. Os parâmetros clínicos periodontais foram: Registro Periodontal Simplificado (PSR), Índice Comunitário de Necessidades de Tratamento Periodontal (CPITN), Índice de Placa (IP), Índice de sangramento sulcular à sondagem (IS), Profundidade de Sondagem (PS), nível de inserção clínica periodontal (NIC) e Retração Gengival (RG). Avaliaram-se também na anamnese e no exame clínico global a idade, etnia, escolaridade, estado civil, hábitos alimentares, pressão arterial pulsátil, índice de massa corpórea (IMC), tabagismo, histórico familiar de cardiopatias, atividade física semanal e presença de doenças sistêmicas. Na avaliação laboratorial analisamos Glicemia, Triglicérides, Lipoproteína de Alta (HDL) e Baixa (LDL) Densidade...

‣ Detecção de periodontopatógenos do complexo vermelho em ateromas de artérias coronárias de pacientes com doença cardiovascular e periodontite crônica; Deteccion of periodontopathogens of the red complex in the atheroma of the coronary arteries from patients with cardiovascular disease and chronic periodontitis

Canonico, Luiz Alberto Dib
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 10/08/2009 Português
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Existe a hipótese, dentro da medicina periodontal, de uma possível relação entre doença periodontal e doenças cardíacas. Talvez a doença periodontal possa agir como um fator desencadeante para o desenvolvimento da doença cardiovascular. Vinte e oito pacientes portadores de aterosclerose e periodontite crônica, submetidos à intervenção cirúrgica de revascularização cardíaca e endarterectomia coronariana, participaram do estudo, cujo objetivo foi avaliar nas placas de ateroma de artérias coronárias a presença dos periodontopatógenos do complexo vermelho: Porphyromonas gingivalis, Tannerella forsythia e Treponema denticola. O DNA genômico foi extraídos das amostras de ateromas e se constatou a presença das bactérias através da reação em cadeia da polimerase (PCR). Detectou-se nas 28 amostras de ateroma: P. gingivalis em 50%, T. forsythia em 7,1% e T. denticola em 3,6% respectivamente. Estes resultados ajudam a defender a hipótese de que a doença periodontal pode ser um dos muitos fatores envolvidos com o desenvolvimento da doença cardiovascular, sendo mais um motivo para ser precocemente diagnosticada, prevenida e tratada.; In the field of periodontal medicine there is the hypothesis of a possible connection between periodontal diseases and heart diseases. Maybe the periodontal disease may work as a triggering factor in the development of periodontal of cardiovascular diseases. Twenty-eight patients of atherosclerosis and cronical periodontitis patients were subjected to surgical intervention for cardiac revascularization and coronary endarterectomy...

‣ Efeito da Síndrome dos Ovários Policísticos em múltiplos marcadores ultrassonográficos e laboratoriais de risco metabólico e doença cardiovascular em mulheres obesas sem outras condições de saúde que interferem com critérios de elegibilidade de contraceptivo oral combinado; Effect of polycystic ovary syndrome on multiple ultrasonographic and laboratorial markers of metabolic and cardiovascular disease risk in obese women without any other health condition that interferes with combined oral contraceptive elegibility criteria: a case-control study

Zueff, Lucimara Facio Nobre
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 04/10/2011 Português
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OBJETIVO: Avaliamos se a presença da síndrome dos ovários policísticos (SOP) altera múltiplos marcadores ultrassonográficos e laboratoriais de risco metabólico e doença cardiovascular em mulheres obesas sem outras condições que interferem com o critério de elegibilidade do contraceptivo oral combinado (COC). MÉTODOS: Estudo caso-controle avaliando 90 mulheres obesas ( 30,0 Kg/m² e < 40 Kg/m²), com idade entre 18 e 40 anos, sem outras condições de saúde que interferem com os critérios de elegibilidade de COC: 45 com SOP e 45 controles, pareadas por idade. Índice de massa corporal; circunferência da cintura e do quadril; pressão arterial sanguínea; insulina e glicemia de jejum; quantitative insulin sensitivity check index (QUICKI); HDL, LDL e colesterol total; triglicérides; testosterona; globulina carreadora de hormônios sexuais (SHBG); índice de androgênio livre (FAI); índice de rigidez da carótida e espessura íntimamédia (EIM); dilatação mediada por fluxo da artéria braquial (DMF) e doença hepática gordurosa não alcoólica (DHGNA) foram avaliados. RESULTADOS: Em mulheres obesas com SOP, observamos uma maior freqüência de DHGNA quando comparada a obesas sem SOP (73,4% vs. 46,6%, p<0,01). Embora não significativo...

‣ Marcadores precoces de doença cardiovascular em mulheres com síndrome dos ovários policísticos; Early markers of cardiovascular disease in women with polycystic ovary syndrome

Soares, Gustavo Mafaldo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 08/08/2008 Português
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Introdução:A síndrome dos ovários policísticos (SOP) é a endocrinopatia mais comum em mulheres no menacme, com prevalência variando de 5 a 10%. A SOP está associada à elevação do risco cardiovascular e eventos metabólicos adversos, incluindo obesidade, resistência à insulina, dislipidemia e inflamação crônica de baixo grau. Apesar dos fatores de risco cardiovascular serem mais prevalentes em mulheres com SOP, não existe evidência científica de maior incidência de doença cardiovascular (DCV) nestas mulheres. Vários estudos reportaram alterações em marcadores de risco para DCV na SOP, porém ainda não foram determinados quais os marcadores ideais para a detecção precoce da DCV. Objetivo:Avaliar a presença de marcadores precoces de DCV em mulheres jovens e não-obesas com SOP. Casuística e Métodos:Foram incluídas 39 pacientes com SOP e 50 mulheressaudáveis, com ciclos menstruais regulares e pareadas por idade e índice de massa corporal (IMC). Através da ultra-sonografia foram avaliados os seguintes marcadores de DCV: índice de rigidez da artéria carótida comum, distensibilidade da artéria carótida comum, espessura da camada íntima-média da artéria carótida comum (IMT) e dilatação mediada pelo fluxo da artéria braquial (DMF). Foram avaliadas ainda variáveis antropométricas...

‣ From hypertrophic cardiomyopathy centers to inherited cardiovascular disease centers in Europe. A small or a major step? A position paper from the Nucleus of the Working Group on Myocardial and Pericardial Diseases of the Portuguese Society of Cardiology.

Cardim, N; Freitas, A; Brito, D
Fonte: Sociedade Portuguesa de Cardiologia Publicador: Sociedade Portuguesa de Cardiologia
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
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The prevalence, complexity, clinical importance, heterogeneity and unpredictability of inherited cardiovascular diseases make the development of inherited cardiovascular disease centers an inevitability, with the ultimate goal of reducing the morbidity and mortality associated with these conditions. An inherited cardiovascular disease center may be seen as a subunit of a cardiology department, with health professionals specializing in these types of disorders, organized to provide excellence in all related areas, including diagnosis, treatment, followup, prevention, risk stratification and prognosis. Among its objectives are the development of action protocols and the creation of databases that enable patients to be included in national and international research networks. To achieve these objectives these centers should include functional units of clinical and basic sciences, research, training and education, acting in harmony in a holistic approach to patients and their families. As most experience on inherited cardiovascular diseases is based on hypertrophic cardiomyopathy and on "hypertrophic cardiomyopathy centers", these centers represent an excellent opportunity to learn how to set up inherited cardiovascular disease centers. European centers will differ from country to country...

‣ Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma

Paz-Filho,Gilberto; Licinio,Julio; Wong,Ma-Li
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2010 Português
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OBJECTIVE: To describe the pathophysiological basis linking cardiovascular disease (CVD) and depression; to discuss the causal relationship between them, and to review the effects of antidepressant treatment on cardiovascular disease. METHOD: A review of the literature based on the PubMed database. DISCUSSION: Depression and cardiovascular disease are both highly prevalent. Several studies have shown that the two are closely related. They share common pathophysiological etiologies or co-morbidities, such as alterations in the hypothalamic-pituitary axis, cardiac rhythm disturbances, and hemorheologic, inflammatory and serotoninergic changes. Furthermore, antidepressant treatment is associated with worse cardiac outcomes (in case of tricyclics), which are not observed with selective serotonin reuptake inhibitors. CONCLUSION: Although there is a strong association between depression and cardiovascular disease, it is still unclear whether depression is actually a causal factor for CVD, or is a mere consequence, or whether both conditions share a common pathophysiological etiology. Nevertheless, both conditions must be treated concomitantly. Drugs other than tricyclics must be used, when needed, to treat the underlying depression and not as mere prophylactic of cardiac outcomes.

‣ Influenza Vaccination of Persons with Cardiovascular Disease in the United States

Singleton, James A.; Wortley, Pascale; Lu, Peng-Jun
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em //2004 Português
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People who have cardiovascular disease are at increased risk of hospitalization or death associated with influenza infection, and are included among the high-risk groups for whom annual influenza vaccination is recommended. To measure the progress toward the national year 2000 and 2010 objectives of a 60% annual influenza vaccination of adults with high-risk conditions aged 18 to 64 years, we analyzed data from the 1997 to 2001 National Health Interview Surveys (NHIS) regarding persons with cardiovascular disease. The NHIS is an annual, cross-sectional survey representative of the U.S., noninstitutionalized, civilian population. Estimated percentages of persons with heart disease reporting influenza vaccination were relatively stable during the 1996–97 through 2000–2001 influenza seasons, with the highest levels in most groups occurring in 1999–2000: 49.2% (95% confidence interval [CI], 44.1%–54.3%) among persons aged 50 to 64 years; and 22.7% (95% CI, 18.2%–27.2%) among persons aged 18 to 49 years. Influenza vaccine coverage among adults aged 18 to 64 years with cardiovascular disease is substantially below the national objective. Multiple strategies are needed to improve vaccination coverage, such as increasing the awareness of and demand for vaccination by persons with heart disease; increasing implementation by providers of practices that have been shown to increase vaccination levels; and adopting of influenza vaccination by primary care providers and specialists as a standard of care for persons diagnosed with cardiovascular disease.

‣ Dairy and Cardiovascular Disease: A Review of Recent Observational Research

Rice, Beth H.
Fonte: Springer US Publicador: Springer US
Tipo: Artigo de Revista Científica
Português
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The consumption of dairy, including milk, cheese and yogurt, has been associated with better quality of diet and reduced risk of cardiovascular disease, the leading cause of death globally. The purpose of this review is to examine recent literature on the relationship between dairy consumption and risk of cardiovascular disease incidence and mortality. Eighteen observational studies were reviewed, the results of which indicate that total dairy intake does not contribute to cardiovascular disease incidence or death. Based on available data, it appears that milk, cheese, and yogurt are inversely associated with cardiovascular disease risk. Data pertaining to dairy fat were inconclusive, but point to a potential protective effect of full-fat milk, cheese, and yogurt on risk of cardiovascular disease. Currently, there is a need to study specific well-defined foods, as opposed to calculating nutrients, in order to better understand these relationships. Future research need not replicate the body of literature on total dairy consumption and associated risk of disease, but rather should focus on the effects of individual dairy foods on cardiovascular events in male and female populations.

‣ Workplace exposure to passive smoking and risk of cardiovascular disease: summary of epidemiologic studies

Kawachi, Ichiro; Colditz, Graham A.
Fonte: National Institute of Environmental Health Sciences Publicador: National Institute of Environmental Health Sciences
Tipo: Artigo de Revista Científica
Português
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We reviewed the published epidemiologic studies addressing the relationship between workplace exposure to environmental tobacco smoke (ETS) and cardiovascular disease risk in three case-control studies and three cohort studies. Although the point estimates of risk for cardiovascular disease exceeded 1.0 in five of six studies, none of the relative risks was statistically significant because of the small number of cardiovascular end points occurring in individual studies. In common with most epidemiologic investigations of the health risks of ETS, none of the workplace studies included independent biochemical validation of ETS exposure. In contrast to the evidence on increased cardiovascular disease risk from exposure to spousal ETS, studies of ETS exposure in the workplace are still sparse and inconclusive. Conversely, there is no biologically plausible reason to believe that the hazards of ETS exposure that have been demonstrated in the home should not also apply to the workplace.

‣ Differences in the Risk of Cardiovascular Disease among People with HIV, Hepatitis C, or Co-infection

Kakinami, Lisa ; Fisher, Susan G.
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Tese de Doutorado
Português
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Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Community & Preventive Medicine, 2010.; Background: With the availability of effective antiretrovirals, HIV patients are living longer, and cardiovascular disease (CVD) risk is a growing concern. One third of HIV patients are co-infected with Hepatitis C (HCV), but the risk of CVD in this population is not well defined. The total cholesterol/high-density lipoprotein ratio (TC/HDL-C ratio) and the Framingham Risk Score (FRS) are robust measures of CVD risk but have not been examined in the context of HIV/HCV co-infected patients. Methods: Our study had four specific aims and utilized data from Strong Memorial Hospital, AIDS Community Health Center, Unity Health and the National Health and Nutrition Examination Survey (NHANES). Aim 1: We compared the TC/HDL-C ratio among subjects with HIV (n=221), HCV (n=194), or HIV/HCV co-infection (n=153) that were not on HIV antiretrovirals. Aim 2: We compared the mean change in the baseline TC/HDL-C ratio after greater than six months of HIV antiretroviral use between HIV (n=132) and HIV/HCV co-infected subjects (n=74). Aim 3: We compared the FRS among subjects with HIV (n=262), HCV (n=181), or HIV/HCV co-infection (n=196). Aim 4: We compared the FRS from our subjects in Aim 3 matched 3:1 on age and sex to subjects from the 2003-2006 NHANES. Multivariate analyses included linear and logistic regressions and adjusted for important demographic and health characteristics identified in the bivariate analyses. Results: For each aim...

‣ Body mass index and cardiovascular disease in the Asia-Pacific Region: An overview of 33 cohorts involving 310 000 participants

Ni Murchu, C.; Rodgers, A.; Pan, W.H.; Gu, D.; Woodward, M.; Parag, V.; Lin, R.; Bennett, D.; Vander Hoorn, S.; Barzi, F.; MacMahon, S.; Lam, T.; Lawes, C.; Sun, I.; Ueshima, H.; Okayama, A.; Maegawa, H.; Aoki, N.; Nakamura, M.; Kubo, N.; et al.
Fonte: Oxford Univ Press Publicador: Oxford Univ Press
Tipo: Artigo de Revista Científica
Publicado em //2004 Português
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Background Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m2 lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent...

‣ Predictors of long-Term adherence to Continuous Positive Airway Pressure Therapy in Patients with obstructive sleep apnea and cardiovascular disease in the SAVE Study

Chai-Coetzer, C.; Luo, Y.M.; Antic, N.; Xi-Long, Z.; Chen, B.Y.; He, Q.Y.; Heeley, E.; Huang, S.G.; Anderson, C.; Zhong, N.S.; McEvoy, R.
Fonte: Amer Academy Sleep Medicine Publicador: Amer Academy Sleep Medicine
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
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STUDY OBJECTIVES: To determine the clinical variables that best predict long- term continuous positive airway pressure (CPAP) adherence among patients with cardiovascular disease who have obstructive sleep apnea (OSA). DESIGN: 12-mo prospective within-trial observational study. SETTING: Centers in China, Australia, and New Zealand participating in the Sleep Apnea cardioVascular Endpoints (SAVE) study. PATIENTS: There were 275 patients age 45-70 y with cardiovascular disease (i.e., previously documented transient ischemic attack, stroke, or coronary artery disease) and OSA (4% oxygen desaturation index (ODI) > 12) who were randomized into the CPAP arm of the SAVE trial prior to July 1, 2010. METHODS: Age, sex, country of residence, type of cardiovascular disease, baseline ODI, severity of sleepiness, and Hospital Anxiety and Depression Scale (HADS) scores plus CPAP side effects and adherence at 1 mo were entered in univariate analyses in an attempt to identify factors predictive of CPAP adherence at 12 mo. Variables with P < 0.2 were then included in a multivariate analysis using a linear mixed model with sites as a random effect and 12-mo CPAP use as the dependent outcome variable. MEASUREMENTS AND RESULTS: CPAP adherence at 1, 6, and 12 mo was (mean ± standard deviation) 4.4 ± 2.0...

‣ Spatial analysis of pregnancy complications associated with maternal cardiovascular disease risk in Ontario

Stortz, Jessica
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado
Português
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Aim: The aim of this study was to: 1) investigate the geographic distribution of six pregnancy complications associated with future maternal cardiovascular disease risk in the province of Ontario and 2) to identify regions where women are likely to benefit from post-partum cardiovascular disease screening, based on the development of complications during pregnancy. Rationale: Cardiovascular disease is the leading cause of death in Canadian women. Pregnancy has been likened to a cardiovascular stress test and provides an early opportunity to assess a female’s lifetime risk of cardiovascular disease. Methods: This study was a retrospective analysis of data collected for the Niday Perinatal Database, provided by the Better Outcomes Registry & Network. Crude and age-standardized cumulative incidences of six pregnancy complications, and one or more pregnancy complications, were calculated for each Public Health Unit area in Ontario. The cumulative incidence of one or more pregnancy complications for women with no previous history of cardiovascular disease or traditional cardiovascular risk factors was calculated at the Public Health Unit and census subdivision area levels. Spatial statistics were applied to locate statistically significant clusters of high cumulative incidence. Results: Crude and age-standardized cumulative incidences of each pregnancy complication and one or more pregnancy complications varied across Public Health Unit areas in Ontario. The crude cumulative incidence of one or more complications ranged from 74 to 224 cases per 1000 pregnancies. The spatial analysis identified one statistically significant cluster of high cumulative incidence at the Public Health Unit area level...

‣ Mixing health and geography: A study of risks associated with cardiovascular disease for the Punjabi Sikh population in the Regional Municipality of Peel

Bains, GURVEER
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado
Português
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The emerging epidemic of cardiovascular disease is threatening the health and well-being of various communities around the world. The risk of cardiovascular disease is amplified for the Punjabi Sikh population of Canada originating from Punjab, India. According to Statistics Canada’s National Household Survey, the Punjabi Sikh community represents approximately 115 000 or 9.3 percent of the total population within the Region of Peel, making it the second largest Punjabi Sikh community in Canada. Therefore, there is an urgent need to understand factors that contribute to the decline in cardiovascular health of this growing sub-population. The research focuses on Punjabi Sikhs who are 55 years of age or older, immigrated to Canada, live in the Region of Peel and have been diagnosed with cardiovascular disease. This age group was selected given that cardiovascular disease diagnosis occurs earlier for Sikhs compared to their ethnic European comparator groups. The Punjabi Sikh population also encompasses an important aging ethnic population in Canada. Health geography plays a vital role in connecting how factors associated with where Punjabi Sikhs live are linked to an increased risk of cardiovascular disease. Through a population health approach...

‣ Lipid profile of nutrition students and its association with cardiovascular disease risk factors

Fisberg,Regina Mara; Stella,Roberta Horschutz; Morimoto,Juliana Masami; Pasquali,Luciana Sicca; Philippi,Sonia Tucunduva; Latorre,Maria do Rosário D. O.
Fonte: Sociedade Brasileira de Cardiologia - SBC Publicador: Sociedade Brasileira de Cardiologia - SBC
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2001 Português
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OBJECTIVE: To describe the lipid profile and to verify its relationship with cardiovascular disease risk factors in students at a public university in São Paulo. METHODS: After obtaining clinical, anthropomorphic, and lipid profile data from 118 students, variables of the lipid profile were related to other risk factors. RESULTS: The mean age of the students was 20.3 years (SD=1.5). The risk of cardiovascular disease was characterized by a positive family history of ischemic heart disease in 38.9%; sedentariness in 35.6%; limiting and increased total and LDL-C cholesterol levels in 17.7% and 10.2%, respectively; decreased HDL-C levels in 11.1%; increased triglyceride levels in 11.1%; body mass index >25 in 8.5%, and smoking in 6.7% of the subjects. Students' diet was found to be inadequate regarding protein, total fat, saturated fat, sodium, and fiber contents. A statistically significant association between cholesterol and contraceptive use, between HDL-C and contraceptive use, age and percent body fat, and triglycerides and percent lean weight was observed. CONCLUSION: A high prevalence of some risk factors of cardiovascular disease as well as the association between these factors with altered lipid profiles was observed in the young population studied.

‣ The Effect of Tobacco Control Measures during a Period of Rising Cardiovascular Disease Risk in India: A Mathematical Model of Myocardial Infarction and Stroke

Basu, Sanjay; Glantz, Stanton; Bitton, Asaf; Millett, Christopher
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Português
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Background: We simulated tobacco control and pharmacological strategies for preventing cardiovascular deaths in India, the country that is expected to experience more cardiovascular deaths than any other over the next decade. Methods and Findings: A microsimulation model was developed to quantify the differential effects of various tobacco control measures and pharmacological therapies on myocardial infarction and stroke deaths stratified by age, gender, and urban/rural status for 2013 to 2022. The model incorporated population-representative data from India on multiple risk factors that affect myocardial infarction and stroke mortality, including hypertension, hyperlipidemia, diabetes, coronary heart disease, and cerebrovascular disease. We also included data from India on cigarette smoking, bidi smoking, chewing tobacco, and secondhand smoke. According to the model's results, smoke-free legislation and tobacco taxation would likely be the most effective strategy among a menu of tobacco control strategies (including, as well, brief cessation advice by health care providers, mass media campaigns, and an advertising ban) for reducing myocardial infarction and stroke deaths over the next decade, while cessation advice would be expected to be the least effective strategy at the population level. In combination...

‣ World Health Organization (WHO) and International Society of Hypertension (ISH) risk prediction charts: assessment of cardiovascular risk for prevention and control of cardiovascular disease in low and middle-income countries

Mendis, Shanthi; Lindholm, Lars H.; Mancia, Giuseppe; Whitworth, Judith; Alderman, Michael; Lim, Stephen; Heagerty, Tony
Fonte: Lippincott Williams & Wilkins Publicador: Lippincott Williams & Wilkins
Tipo: Artigo de Revista Científica
Português
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Cardiovascular disease (CVD) is the leading cause of the growing global disease burden due to non-communicable diseases. For successful prevention and control of CVD, strategies that focus on individuals need to complement population-wide strategies. Stra

‣ Gene-Environment Interactions in Cardiovascular Disease

Ward-Caviness, Cavin Keith
Fonte: Universidade Duke Publicador: Universidade Duke
Tipo: Dissertação
Publicado em //2014 Português
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In this manuscript I seek to demonstrate the importance of gene-environment interactions in cardiovascular disease. This manuscript contains five studies each of which contributes to our understanding of the joint impact of genetic variation and environmental exposures to cardiovascular disease: a candidate gene study for gene-smoking interactions associated with early-onset coronary artery disease, an epidemiology study of the association between traffic-related air pollution and cardiovascular disease, a Genome-Wide Interaction Study for gene-by-traffic related air pollution interactions associated with peripheral arterial disease, a Genome-Wide Interaction Study for gene-by-traffic related air pollution interactions on coronary atherosclerosis burden, and a method for analyzing associations between high-dimensional genomics datasets.

Smoking is a strong risk factors for coronary artery disease, and may play a causative role in the incidence of coronary artery disease. Smoking had been implicated as a reason for heterogeneity observed in associations between genetic variants on chromosome three and coronary artery disease. I used a family-based early-onset coronary artery disease cohort (GENECARD) to study gene-smoking interactions. I also used data from the three independent cohorts to perform a meta-analysis of gene-smoking interactions focusing on the KALRN gene and Rho-GTPase pathway. I found significant evidence for gene-smoking interactions associations involving variants in KALRN and other Rho-GTPase pathway genes on chromosome 3.

Though the estimated increase in incident cardiovascular disease or cardiovascular events due to air pollution exposure is modest at 3-5%...

‣ Localized Correlation Analysis and Genetic Association with Cardiovascular Disease

Ou, Chern-Han
Fonte: Universidade Duke Publicador: Universidade Duke
Tipo: Tese de Doutorado Formato: 8483044 bytes; application/pdf
Publicado em //2010 Português
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Variations in gene expression are potential risk factors for atherosclerosis, which is one of the most common forms of cardiovascular disease. We performed a localized Pearson correlation test in 372 individuals from seven datasets relevant to cardiovascular disease studies. The genomes of samples were separated into 20Mb windows and correlation tests were performed locally in these windows. The localized Pearson correlation test found chr3:115Mb–135Mb was tightly connected by significantly high proportion of highly correlated pairs (P value = 0.0266 with Z-test). LSAMP, GATA2, MBD4, and other genes in the region were considered associated with cardiovascular disease because they were involved in highly correlated pairs. Furthermore, these genes were also associated with cardiovascular disease by having significantly high SNP odds ratios (P value < 0.1) between patients and controls in an independent Duke University Medical Center database. In addition, a permutation test was performed to demonstrate that chr3:115Mb–135Mb might underlie the regulation of cardiovascular disease. Finally, the localized Pearson correlation test also found some other regions that could be associated with cardiovascular disease.

; Thesis

‣ Depression among cardiovascular disease patients on a consultation-liaison service at a General Hospital in Jamaica

Martin,JS; Neita,SM; Gibson,RC
Fonte: West Indian Medical Journal Publicador: West Indian Medical Journal
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2012 Português
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OBJECTIVE: The prevalence of cardiovascular disease in Jamaica and other Caribbean countries has been steadily rising. Depression has been associated with increased morbidity and mortality in patients with cardiovascular disease. Against this background, the authors compared the co-occurrence of depressive illnesses among general hospital inpatients with cardiovascular disease and those without cardiovascular disease. METHOD: Psychiatric and non-psychiatric diagnoses on all inpatients referred to the consultation-liaison psychiatry service at a general hospital in Jamaica were recorded over a one-year period and analysed using chi-square, t-tests, binary logistic regression and odds ratio. Statistical significance was taken at the 0.05 level. RESULTS: Of the 201 patients referred, 17.9% had cardiovascular disease and 19.9% had depressive illnesses. One third of patients with cardiovascular disease were depressed. They were also significantly more likely than other patients to have a depressive illness (OR = 2.93, 95% CI: 1.25, 6.85). CONCLUSION: Special attention to the prevention, detection and treatment of depression should be applied to patients with cardiovascular disease.